Hubbard GP, Wolffram S, Lovegrove JA, Gibbins JM. Isolated quercetin is also marketed as a dietary supplement, mostly as the free quercetin aglycone, and frequently in daily doses of up to 1000 mg d-1 exceeding usual dietary intake levels. Eur J Clin Nutr 1999;53:92-6. Loke, W. M., Hodgson, J. M., Proudfoot, J. M., McKinley, A. J., Puddey, I. Nieman DC, Henson DA, Davis JM, et al. Quercetin reduces blood pressure in hypertensive subjects. Crespy, V., Morand, C., Manach, C., Besson, C., Demigne, C., and Remesy, C. Part of quercetin absorbed in the small intestine is conjugated and further secreted in the intestinal lumen. 2014;66(2):119-25. Erlund, I., Alfthan, G., Maenpaa, J., and Aro, A. Note: This document contains side effect information about bioflavonoids. Beatty, E. R., O'Reilly, J. D., England, T. G., McAnlis, G. T., Young, I. S., Geissler, C. A., Sanders, T. A., and Wiseman, H. Effect of dietary quercetin on oxidative DNA damage in healthy human subjects. No side effects were reported. 2003;71(6):448-454. Taking quercetin along with these medications that are changed by the liver might increase the effects and side effects of your medication. J Nutr 2007;137:2405-11. Enhanced paclitaxel bioavailability after oral administration of paclitaxel or prodrug to rats pretreated with quercetin. Some medications are changed and broken down by the liver. Guo Y, Mah E, Davis CG, et al. View abstract. Nemeth K, Piskula MK. Crit Rev Food Sci Nutr. Quercetin Phytosome (Sophora japonica concentrate (leaf) / Phosphatidylcholine complex from Sunflower) 250 mg. Other Ingredients: Hypromellose (derived from cellulose) capsule, Microcrystalline Cellulose, Leucine, Silicon Dioxide. View abstract. View abstract. The effect of quercetin on inflammatory factors and
© 2005 - 2021 WebMD LLC. Wang SY, Duan KM, Li Y, et al. Xenobiotica 2019;49(5):563-8. Probably its most well-known mechanism of action involves stabilization of mast cell membranes, which helps to decrease … View abstract. Am.J Clin Nutr. Nieman DC, Henson DA, Davis JM, et al. Vitamin C plus ultra-absorbable quercetin for immune support. Effect of emulin on blood glucose in type 2 diabetics. Curr.Urol.Rep. Effects of the flavonoids quercetin and apigenin on hemostasis in healthy volunteers: results from an in vitro and a dietary supplement study. Quercetin Phytosome is safe for most users. 2000;46(8 Pt 1):1162-1170. Naunyn Schmiedebergs Arch Pharmacol 2003;368:200-9. Quercetin-loaded phytosome nanoparticles (QP) prepared by thin film hydration method. DiCenzo R, Frerichs V, Larppanichpoonphol P, et al. J Clin Diagn Res. All that said, it is important to note that some people do experience side effects. This might cause more side effects from some medications.Some medications that are moved by these pumps include diltiazem (Cardizem), verapamil (Calan, Isoptin, Verelan), digoxin (Lanoxin) cyclosporine (Neoral, Sandimmune), saquinavir (Invirase), amprenavir (Agenerase), nelfinavir (Viracept), loperamide (Imodium), quinidine, paclitaxel (Taxol), vincristine, etoposide (VP16, VePesid), cimetidine (Tagamet), ranitidine (Zantac), fexofenadine (Allegra), ketoconazole (Nizoral), itraconazole (Sporanox), and others. Lung cancer. It has also been reported in rat that higher concentrations of quercetin cause nerve cell damage with equal chances of apoptosis … View abstract. Effect of quercetin on CYP3A activity in Chinese healthy participants. Altern.Med.Rev. View abstract. View abstract. Int J Sport Nutr Exerc Metab 2013;23(1):73-82. View abstract. Thorne Research Quercetin Phytosome Side Effects. Quercetin Phytosome® has shown to produce much better absorption and clinical results than regular quercetin. View abstract. A. Quercetin oral supplements aren’t likely to cause adverse reactions or side effects in most people, but some individuals have reported digestive upset after taking it. Eur J Pharm Sci 2014;61:54-60. Effects of quercetin supplementation on glycemic control among patients with metabolic syndrome and related disorders: a systematic review and meta-analysis of randomized controlled trials. Chronic quercetin ingestion and exercise-induced oxidative damage and inflammation. aggregatum) is more bioavailable than its glucosides. Mol Nutr Food Res 2013;57(5):896-905. View abstract. Quercetin reduces illness but not immune perturbations after intensive exercise. 2007;8(4):313-318. Tea and coronary heart disease: the flavonoid quercetin is more bioavailable from rutin in women than in men. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you. Early research shows that taking quercetin might improve asthma symptoms and reduce the use of rescue inhalers in people with asthma. View abstract. In a clinical study published in the European Journal of Drug Metabolism and Pharmacokinetics in 2018, quercetin administered with phytosome technology was found to facilitate up to 20 times plasma levels of quercetin, compared to unformulated quercetin. Medically reviewed by Drugs.com. Pharmacokinetics of quercetin from quercetin aglycone and rutin in healthy volunteers. It is found in many plants and foods, such as red wine, onions. J Clin Pharmacol 2005;45:941-6. J Nutr 2001;131:745-8. Sahebkar A. View abstract. J Strength Cond Res 2012;26 Suppl 2:S53-60. Suardi N, Gandaglia G, Nini A, et al. Quercetin is a flavonoid that complements vitamin C’s health benefits. Side Effects, Risks and Interactions. Minerva Med 2019;110(6):524-9. Training was considered more valuable in the quercetin group compared with controls (P<0.05). clinical symptoms in women with rheumatoid arthritis: A double-blind, randomized controlled trial. See the “Side Effects” section for more precautions before supplementing with Quercetin. View abstract. J Med Food. Before taking quercetin talk to your healthcare provider if you take any medications that are changed by the liver.Some medications that are changed by the liver include amitriptyline (Elavil), codeine, flecainide (Tambocor), haloperidol (Haldol), imipramine (Tofranil), metoprolol (Lopressor, Toprol XL), ondansetron (Zofran), paroxetine (Paxil), risperidone (Risperdal), tramadol (Ultram), venlafaxine (Effexor), and others. Beneficial effects of the bioflavonoids curcumin and quercetin on early function in cadaveric renal transplantation: a randomized placebo controlled trial. Shoskes D, Lapierre C, Cruz-Corerra M, et al. 2014;66(4):225-32. Nguyen MA, Staubach P, Wolffram S, Langguth P. Effect of single-dose and short-term administration of quercetin on the pharmacokinetics of talinolol in humans - Implications for the evaluation of transporter-mediated flavonoid-drug interactions. Conquer JA, Maiani G, Azzini E, et al. View abstract. Quercetin, a promising clinical candidate for the prevention of contrast-induced nephropathy. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. View abstract. Plasma concentrations and urinary excretion of the antioxidant flavonols quercetin and kaempferol as biomarkers for dietary intake. Effect of quercetin on the pharmacokinetics of rosiglitazone, a CYP2C8 substrate, in healthy subjects. View abstract. Heart disease. You may report them to the FDA. 2016;5(7). Effects of quercetin on adiponectin-mediated insulin sensitivity in polycystic ovary syndrome: A randomized placebo-controlled double-blind clinical trial. One population study found no link between quercetin intake from the diet and the chance of ovarian cancer. Some have report stomach discomfort when taken on an empty stomach. Eur.J.Clin.Pharmacol. Boots, A. W., Haenen, G. R., and Bast, A. Best In Class . Cesarone MR, Belcaro G, Hu S, et al. Nutr Res. Terao, J., Kawai, Y., and Murota, K. Vegetable flavonoids and cardiovascular disease. Very high dosages of Quercetin may be damaging to the kidneys. View abstract. de Pascual-Teresa S, Johnston KL, DuPont MS, et al. Clin Ther. • Superiority of QP over free quercetin at same doses as a promising HRT. Inhibition of human cytochrome P450 enzymes by constituents of St. John's wort, an herbal preparation used in the treatment of depression. Kang, L. P., Qi, L. H., Zhang, J. P., Shi, N., Zhang, M., Wu, T. M., and Chen, J. Sajadi Hezaveh Z, Azarkeivan A, Janani L, Hosseini S, Shidfar F. The effect of quercetin on iron overload and inflammation in Ã-thalassemia major patients: a double-blind randomized clinical trial. Nishijima T, Takida Y, Saito Y, Ikeda T, Iwai K. Simultaneous ingestion of high-methoxy pectin from apple can enhance absorption of quercetin in human subjects. View abstract. Hollman, PC, Bijsman, MN, van Gameren, Y, Cnossen, EP, de Vries, JH, and Katan, MB. You are here: Products Life Extension Vitamin C with Bio-Quercetin Phytosome, 250 Tablets. 500 mg (supplying 250 mg quercetin) [quercetin dihydrate, buckwheat (sprout), apple polyphenol extract (fruit), onion extract (bulb)] Camu-camu extract (wildcrafted berry) 60 mg. Other ingredients: vegetable cellulose (capsule), microcrystalline cellulose, silica, maltodextrin, stearic acid. Janssen K, Mensink RP, Cox FJ, et al. Eur J Obstet Gynecol Reprod Biol. 2020;71(2):152-163. 2000;5(3):196-208. Anon. 2020;78(8):615-626. Quercetin might decrease how quickly the liver breaks down some medications. Some potential side effects that have been observed in humans include upset stomach and headaches. 2013;16(3):211-5. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. Ingestion of quercetin inhibits platelet aggregation and essential components of the collagen-stimulated platelet activation pathway in humans. 2012;32(8):557-64. These side effects may go away during treatment as your body adjusts to the medicine. Rayalam, S., Della-Fera, M. A., and Baile, C. A. Phytochemicals and regulation of the adipocyte life cycle. Because it’s derived naturally from foods, quercetin seems to be safe for almost everyone and poses little risks. 2001;22(9):793-796. Biol Trace Elem Res 1998;62:135-53. View abstract. 2001;131(10):2648-2652. Taking quercetin doesn't seem to help to prevent muscle soreness due to cycling or running. Br J Clin Pharmacol 2012;73(5):750-7. Goldberg DM, Yan J, Soleas GJ. Hardening of the arteries (atherosclerosis). Conclusions A more soluble formulation of quercetin based on lecithin, Quercetin Phytosome, has recently been developed, and was found to facilitate the attainment of very high plasma levels … This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Uncontrolled Blood Sugar: How Dangerous Is It? Quercetin Phytosome offers advanced phytosome technology for optimal absorption. A prospective study to evaluate the efficacy of Cistiquer in improving lower urinary tract symptoms in females with urethral syndrome. Food content, processing, absorption and metabolism of onion flavonoids. Int J Food Sci Nutr. Phytother Res. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Before taking quercetin talk to your healthcare provider if you take any medications that are changed by the liver.Some medications that are changed by the liver include lovastatin (Mevacor), clarithromycin (Biaxin), cyclosporine (Neoral, Sandimmune), diltiazem (Cardizem), estrogens, indinavir (Crixivan), triazolam (Halcion), verapamil (Calan, Isoptin, Verelan), alfentanil (Alfenta), fentanyl (Sublimaze), losartan (Cozaar), fluoxetine (Prozac), midazolam (Versed), omeprazole (Prilosec), lansoprazole (Prevacid), ondansetron (Zofran), propranolol (Inderal), fexofenadine (Allegra), amitriptyline (Elavil), amiodarone (Cordarone), citalopram (Celexa), sertraline (Zoloft), ketoconazole (Nizoral), itraconazole (Sporanox), and numerous others.